资讯详情 资讯详情 资讯详情 资讯详情

染料木素对Iso致心肌肥厚大鼠的抗氧化及抑制炎症反应作用研究

发布日期:2012-11-21 
染料木素对Iso致心肌肥厚大鼠的抗氧化及抑制炎症反应作用研究
Anti-oxidation and Anti-inflammation Effect of Genistein on Myocardial Hypertrophy in Rats Induced by Isopropylarterenol

中国实验方剂学杂志 , Chinese Journal of Experimental Traditional Medical Formulae,
编辑部邮箱,
2012年19期

【作者】 眭荣燕; 王万辉; 连磊凡; 李红燕; 黎晓; 黄志华; 曾靖;

【Author】 SUI Rong-yan1,WANG Wan-hui2,LIAN Lei-fan1,LI Hong-yan1,LI Xiao1,HUANG Zhi-hua1,ZENG Jing3*(1.Basic Medical College of Gannan Medical University,Ganzhou 341000,China; 2.First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China; 3.Pharmaceutical College of Gannan Medical University,Ganzhou 341000,China)

【机构】 赣南医学院基础医学院; 赣南医学院第一附属医院; 赣南医学院药学院;

【摘要】 目的:观察染料木素(Gen)对异丙肾上腺素(Iso)所致心肌肥厚大鼠的抗氧化及抑制炎症反应作用。方法:采用背部sc给予Iso 1 mg.kg-1.d-1,连续10 d,建立大鼠心肌肥厚模型。造模第2天,正常对照组及模型组于背部sc给予NS2 mL.kg-1.d-1,溶剂对照组给予等体积7%DMSO,Gen组给予等体积的Gen 0.03,0.1,0.3μmol.kg-1,连续14 d。末次给药后禁食12 h,称体重,麻醉,取静脉血,分离血清,取心脏,称左心室质量,计算左心室质量参数;检测血清超氧化物歧化酶(superoxide dismutase,SOD)、髓过氧化物酶(myeloperoxidase,MPO)活性及丙二醛(malondialdehyde,MDA)含量;放射免疫学方法检测心肌组织白细胞介素2(interleukin-2,IL-2)含量。结果:与正常对照组相比,模型组大鼠左心室质量参数明显升高(2.48±0.11)mg.kg-1,P<0.001,血清SOD活性明显降低(128.19±11.20)U.mL-1,P<0.05,血清MDA含量增高(15.81±1.96... 更多

【Abstract】 Objective:To observe the antioxidation and anti-inflammation effect of genistein(Gen) on rat myocardial hypertrophy caused by isopropylarterenol(Iso).Method:The rat myocardial hypertrophy model was reproduced through hypodermic injection which lasted 10 days at back skin with Iso,1 mg · kg-1 · d-1.Once the model was succesfully made,rats were administrated with corresponding doses of Gen,DMSO or normal saline through hypodermic injection from the second day,and the process lasted 14 days.After t... 更多
【关键词】 染料木素; 异丙肾上腺素; 心肌肥厚; 抗氧化作用; 抗炎症反应;
【Key words】 genistein; isopropylarterenol; myocardial hypertrophy; antioxidation,anti-inflammation effect;
【基金】 江西省卫生厅科技项目(20093191)
相关文章:

暂无